ARID1A antibody (AA 1800-2000)

Catalog No. ABIN7859298

The Mouse Monoclonal anti-ARID1A antibody is suitable to detect ARID1A in samples from Human. It has been validated for IHC.

Quick Overview for ARID1A antibody (AA 1800-2000) (ABIN7859298)

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ARID1A antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: ARID1A-7736

Product Details anti-ARID1A Antibody

Binding Specificity: AA 1800-2000

Purpose: ARID1A / SMARCF1 Antibody

Specificity: The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2a) and Brg-1 (also designated SNF2b) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits, such as BAF250a (p270 or ARID1A) and BAF250b (ARID1B), are thought to play regulatory roles.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1800-2000) of human ARID1A protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for ARID1A

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Alternative Name: ARID1A

Background:

actin-dependent regulator of chromatin subfamily F member 1, ARID domain containing protein 1A, AT rich interactive domain 1A (SWI like), AT rich interactive domain containing protein 1A, B120, BAF250, BAF250A, BM029, brain protein 120, BRG1-associated factor 250a, C1ORF4, chromatin remodeling factor p250, chromosome 1 open reading frame 4, ELD, hELD, hOSA1, matrix-associated, MRD14, OSA1 nuclear protein, P270, SMARCF1, SWI-like protein, SWI/SNF complex protein p270, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1

Highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and PBL, and at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.

Molecular Weight: 165-320kDa

Gene ID: 8289, 468972

UniProt: O14497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation