TGF-beta antibody (AA 200-390)

Catalog No. ABIN7864527

The Mouse Monoclonal anti-TGF-beta antibody is suitable to detect TGF-beta in samples from Human. It has been validated for IHC.

Quick Overview for TGF-beta antibody (AA 200-390) (ABIN7864527)

Target: TGF-beta (TGFb)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGF-beta antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TGFB-7240

Product Details anti-TGF-beta Antibody

Binding Specificity: AA 200-390

Purpose: TGF-beta (Transforming Growth Factor beta) Antibody

Specificity: This MAb recognizes TGF beta 1, 2 and 3. Three TGF≤s have been identified in mammals. TGF≤1, TGF≤2 and TGF≤3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF≤ requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF≤3 protein has approximately 80 % identity to the mature region of both TGF≤1 and TGF≤2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGF≤ s inhibits the growth of epithelial cells and stimulate the growth of mesenchymal cells. 79oΩ

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-390) of human TGFB protein

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for TGF-beta

Target: TGF-beta (TGFb)

Alternative Name: TGF-beta

Background:

ARVD, BSC 1 cell growth inhibitor, CED, Cetermin, Diaphyseal dysplasia 1 (DPD1), Glioblastoma derived T cell suppressor factor (G TSF), Latency-associated peptide (LAP), Polyergin, Transforming growth factor beta 1 (TGF beta1 or TGFB1), TGF beta2 (TGFB2), TGF beta3 (TGFB3), TGFbeta (TGFB)

Salivary gland carcinoma

Molecular Weight: 13kDa

Gene ID: 7040, 645227

UniProt: P01137

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus