PAX2A antibody (AA 200-400)

Catalog No. ABIN7859491

The Mouse Monoclonal anti-PAX2A antibody (Clone PAX2-2994) (ABIN7859491) specifically detects PAX2A in IHC. The antibody is reactive with Human samples.

Quick Overview for PAX2A antibody (AA 200-400) (ABIN7859491)

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX2A antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PAX2-2994

Product Details anti-PAX2A Antibody

Binding Specificity: AA 200-400

Purpose: PAX2 (Renal Cell & Ovarian Carcinoma Marker) Antibody

Specificity: Recognizes a protein of 42kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 200-400) of human PAX2 protein (exact sequence is proprietary)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for PAX2A

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Alternative Name: PAX2

Background:

Paired box 2, paired box protein 2, Paired box protein Pax-2, Paired box protein Pax2, PAX2

NAMALWA cells. Fetal kidney or Renal Cell Carcinoma (RCC) or Ovarian Carcinoma.

Molecular Weight: 42kDa

Gene ID: 5076, 155644

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation