TCF7 antibody (AA 200-400)

Catalog No. ABIN7859521

The Mouse Monoclonal anti-TCF7 antibody (Clone TCF7-7631) (ABIN7859521) specifically detects TCF7 in IHC. The antibody is reactive with Human samples.

Quick Overview for TCF7 antibody (AA 200-400) (ABIN7859521)

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TCF7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TCF7-7631

Product Details anti-TCF7 Antibody

Binding Specificity: AA 200-400

Purpose: TCF7 Antibody

Specificity: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-400) of human TCF7 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for TCF7

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Alternative Name: TCF7

Background:

Transcription Factor 7 (T-Cell Specific, HMG-Box), T-Cell-Specific Transcription Factor 1, T-Cell Factor 7

adrenal gland or colon.|Human spleen|lung

Molecular Weight: 41.6kDa

Gene ID: 6932, 573153

UniProt: P36402

Pathways: WNT Signaling