Recombinant FCER2 antibody (AA 221-321)

Catalog No. ABIN7864001

The Rabbit Monoclonal anti-FCER2 antibody is suitable to detect FCER2 in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant FCER2 antibody (AA 221-321) (ABIN7864001)

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FCER2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: FCER2-8510R

Product Details anti-FCER2 Antibody

Binding Specificity: AA 221-321

Purpose: Recombinant CD23 (Fc Epsilon RII) Antibody

Specificity: CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 221-321) of human FCER2/CD23 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for FCER2

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Alternative Name: CD23

Background:

BLAST-2, C-type lectin domain family 4, member J, Fc fragment of IgE low affinity II receptor, Fc-epsilon-RII, FCER2, FCER2A, FceRII, IgE-binding factor (IGEBF), Immunoglobulin E receptor, low affinity II, Lymphocyte IgE receptor

Human lymph node or tonsil (IHC).

Molecular Weight: 37kDa (soluble form), 45kDa (membrane-bound form)

Gene ID: 2208, 465778

UniProt: P06734

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process