IL-7 antibody (AA 27-177)

Catalog No. ABIN7864941

The Mouse Monoclonal anti-IL-7 antibody is suitable to detect IL-7 in samples from Human. It has been validated for IHC.

Quick Overview for IL-7 antibody (AA 27-177) (ABIN7864941)

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-7 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IL7-4269

Product Details anti-IL-7 Antibody

Binding Specificity: AA 27-177

Purpose: Interleukin-7 (IL-7) Antibody

Specificity: Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor specific chain and the IL-2 receptor ≥ chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of Insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 27-177) corresponding to mature protein of human IL7 (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for IL-7

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Alternative Name: Interleukin-7

Background:

IL 7, IL-7, Il7, Interleukin 7, Interleukin-7, LP-1, Lymphopoietin 1

Human thymus or tonsil tissue.

Molecular Weight: 25kDa

Gene ID: 3574, 591873

Pathways: JAK-STAT Signaling