Recombinant Desmin antibody (AA 270-470)

Catalog No. ABIN7864214

The Rabbit Monoclonal anti-Desmin antibody is suitable to detect Desmin in samples from Human, Rat, Chicken and Hamster. It has been validated for IHC.

Quick Overview for Recombinant Desmin antibody (AA 270-470) (ABIN7864214)

Target: Desmin (DES)

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Chicken, Hamster

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Desmin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DES-8610R

Product Details anti-Desmin Antibody

Binding Specificity: AA 270-470

Purpose: Recombinant Desmin (Muscle Cell Marker) Antibody

Specificity: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain ±-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. 79oΩAntibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. 79oΩ

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 270-470) of human DES protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Desmin

Target: Desmin (DES)

Alternative Name: Desmin

Background:

CMD1I, CSM1, CSM2, DES, Intermediate filament protein

SJRH30 cells. Intestine, Human uterus or leiomyosarcoma.

Molecular Weight: 52kDa

Gene ID: 1674, 594952