Recombinant Desmoglein 3 antibody (AA 300-500)

Catalog No. ABIN7859798

This Rabbit Monoclonal antibody specifically detects Desmoglein 3 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant Desmoglein 3 antibody (AA 300-500) (ABIN7859798)

Target: Desmoglein 3 (DSG3)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Desmoglein 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DSG3-8251R

Product Details anti-Desmoglein 3 Antibody

Binding Specificity: AA 300-500

Purpose: Recombinant Desmoglein-3 (Squamous Cell Marker) Antibody

Specificity: Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members are identified and all are members of the cadherin cell adhesion molecule superfamily.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa300-500) of human DSG3 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Desmoglein 3

Target: Desmoglein 3 (DSG3)

Alternative Name: Desmoglein-3

Background:

130 kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3)

A431 cells. Lung squamous cell carcinoma.

Molecular Weight: 130kDa

Gene ID: 1830, 1925