EZH2 antibody (AA 300-550)

Catalog No. ABIN7859845

The Mouse Monoclonal anti-EZH2 antibody (Clone EZH2-7507) (ABIN7859845) specifically detects EZH2 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for EZH2 antibody (AA 300-550) (ABIN7859845)

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EZH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: EZH2-7507

Product Details anti-EZH2 Antibody

Binding Specificity: AA 300-550

Purpose: EZH2 / KMT6 Antibody

Specificity: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa300-550) of human EZH2 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for EZH2

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Alternative Name: EZH2

Background:

Enhancer of zeste 2 polycomb repressive complex 2 subunit, Enhancer of zeste homolog 2 (EZH2), ENX1, Enx1h, EZH2b, Histone-lysine N-methyltransferase EZH2, KMT6, KMT6A, Lysine N-methyltransferase 6, WVS, WVS2

HeLa|MCF7|testis or prostate tissue.|U-2 OS or HEK-293, HDLM-2 whole cell lysates. Human tonsil, Placenta tissue

Molecular Weight: 81-102kDa

Gene ID: 2146, 444082

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation