GBP1 antibody (AA 400-592)

Catalog No. ABIN7864723

The Mouse Monoclonal anti-GBP1 antibody (Clone GBP1-7618) (ABIN7864723) specifically detects GBP1 in IHC. The antibody is reactive with Human samples.

Quick Overview for GBP1 antibody (AA 400-592) (ABIN7864723)

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GBP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: GBP1-7618

Product Details anti-GBP1 Antibody

Binding Specificity: AA 400-592

Purpose: GBP1 Antibody

Specificity: GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa400-592) of human GBP1 protein (exact sequence is proprietary)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for GBP1

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Alternative Name: GBP1

Background:

GTP binding protein 1, Guanine nucleotide binding protein 1, Guanylate binding protein 1 interferon inducible 67 kDa, HuGBP1, Interferon induced guanylate binding protein 1, OTTHUMP00000012352

Human colon or cerebral cortex tissue.

Molecular Weight: 67kDa

Gene ID: 2633, 62661

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin