CD207 antibody (AA 50-250)

Catalog No. ABIN7860229

The Mouse Monoclonal anti-CD207 antibody (Clone LGRN-7541) (ABIN7860229) specifically detects CD207 in IHC. The antibody is reactive with Human samples.

Quick Overview for CD207 antibody (AA 50-250) (ABIN7860229)

Target: CD207 (CD207 Molecule, Langerin (CD207))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD207 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: LGRN-7541

Product Details anti-CD207 Antibody

Binding Specificity: AA 50-250

Purpose: Langerin / CD207 (Marker of Langerhans Cells) Antibody

Specificity: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa50-250) of human Langerin protein (exact sequence is proprietary)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Alternative Name: Langerin

Background:

C-type lectin domain family 4 member K, CD207, CLEC4K, Langerhans cell specific c type lectin, Langerin

Human skin.

Molecular Weight: 48kDa

Gene ID: 50489, 199731

UniProt: Q9UJ71