SOX18 antibody (AA 50-250)

Catalog No. ABIN7863909

This Mouse Monoclonal antibody specifically detects SOX18 in IHC. It exhibits reactivity toward Human.

Quick Overview for SOX18 antibody (AA 50-250) (ABIN7863909)

Target: SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOX18 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: SOX18-3271

Product Details anti-SOX18 Antibody

Binding Specificity: AA 50-250

Purpose: SOX18 Antibody

Specificity: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNAbinding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Sox-18 is a 384 amino acid nuclear protein that contains one HMG box DNA-binding domain and belongs to the Sox family of transcriptional regulators.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human SOX18 protein fragment (around aa 50-250) (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for SOX18

Target: SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))

Alternative Name: SOX18

Background:

HLTS, SOX 18, SRY (sex determining region Y) box 18, SRY box 18, Transcription factor SOX-18

Human heart|kidney|skin or endometrium.

Molecular Weight: 45kDa

Gene ID: 54345, 8619

UniProt: P35713