Recombinant Transferrin Receptor antibody (AA 50-250)

Catalog No. ABIN7860275

This Rabbit Monoclonal antibody specifically detects Transferrin Receptor in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant Transferrin Receptor antibody (AA 50-250) (ABIN7860275)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: TFRC-9106R

Product Details anti-Transferrin Receptor Antibody

Binding Specificity: AA 50-250

Purpose: Recombinant CD71 / Transferrin Receptor (TFRC) (Extracellular Domain) Antibody

Specificity: It recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human fragment (around aa50-250) of human TFRC protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: CD71

Background:

Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Human placenta, lungs or bone marrow, PC-3 cell lysate

Molecular Weight: 85-95kDa (monomer), 190kDa (dimer)

Gene ID: 7037, 529618

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis