TGFB3 antibody (AA 50-250)

Catalog No. ABIN7860277

The Mouse Monoclonal anti-TGFB3 antibody (Clone TGFB3-4801) (ABIN7860277) specifically detects TGFB3 in IHC. The antibody is reactive with Human samples.

Quick Overview for TGFB3 antibody (AA 50-250) (ABIN7860277)

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGFB3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TGFB3-4801

Product Details anti-TGFB3 Antibody

Binding Specificity: AA 50-250

Purpose: TGFB3 / PEIG-1 / RAI3 / RAIG1 / TIG1 Antibody

Specificity: Transforming growth factor ≤s (TGF≤s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF≤. TGF≤1, TGF≤2 and TGF≤3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. TGF≤3 mediates many intercellular interactions that occur during embryonic development, cell differentiation and epithelial homeostasis. TGF≤3 overexpresses in extramammary Paget s disease (EPD) and downregulates in Bowen s disease, indicating that its expression is a useful indicator of tumor activity. TGF≤3 levels strongly correlate with IGF-1 and osteocalcin levels in serum. Significant amounts of TGF≤3 circulation appear to be representative of TGF≤3 expression in bone and may in part be derived from bone. Glucocorticoids may block TGF≤ production by modulating mRNA levels and c-Jun activity.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa50-250) of human TGFB3 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for TGFB3

Target: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Alternative Name: TGFB3

Background:

ARVD1, LDS5, prepro-transforming growth factor beta-3, RNHF, TGFB 3, Tgfb3, transforming growth factor beta 3

heart or lung.|Human kidney

Molecular Weight: 13kDa

Gene ID: 7043, 592317

UniProt: P10600

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus