RHOBTB2 antibody (AA 554-604)

Catalog No. ABIN7860391

The Mouse Monoclonal anti-RHOBTB2 antibody (Clone DBC2-3362) (ABIN7860391) specifically detects RHOBTB2 in IHC. The antibody is reactive with Human samples.

Quick Overview for RHOBTB2 antibody (AA 554-604) (ABIN7860391)

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RHOBTB2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DBC2-3362

Product Details anti-RHOBTB2 Antibody

Binding Specificity: AA 554-604

Purpose: DBC2 / RHOBTB2 (Tumor Suppressor) Antibody

Specificity: The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Human recombinant RHOBTB2 protein fragment (around aa554-604) (exact sequence is proprietary)

Isotype: IgG2c, lambda

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for RHOBTB2

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Alternative Name: DBC2

Background:

Deleted in breast cancer 2 gene protein, p83, Rho related BTB domain containing protein 2

Human heart muscle or brain tissue.

Molecular Weight: 83kDa

Gene ID: 23221, 372688

UniProt: Q9BYZ6