APOB antibody (AA 592-689)

Catalog No. ABIN7862964

The Mouse Monoclonal anti-APOB antibody (Clone APOB-4335) (ABIN7862964) specifically detects APOB in IHC. The antibody is reactive with Human samples.

Quick Overview for APOB antibody (AA 592-689) (ABIN7862964)

Target: APOB (Apolipoprotein B (APOB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOB antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: APOB-4335

Product Details anti-APOB Antibody

Binding Specificity: AA 592-689

Purpose: Apolipoprotein B / APOB Antibody

Specificity: Post-transcriptional editing of apolipoprotein B (apoB) mRNA is regulated byAPOBEC1 (also designated human (or rat) small intestinal apolipoprotein B mRNA editing protein, HEPR or REPR) in hepatic cells to achieve a steady state proportion of edited and unedited RNA molecules. Two forms of apoB are known to circulate in the plasma of mammals. ApoB-100 is a protein primarily synthesized in the liver as a structural component of very low density lipoprotein particles. A truncated form of apoB-100, apoB-48, is synthesized in the small intestine and contains the amino-terminal 2,152 amino acids of the larger protein. This organ-specific partitioning of apoB production is the result of RNA editing of a common apoB gene.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Human recombinant APOB protein fragment (around aa 592-689) (exact sequence is proprietary)

Isotype: IgG2b, IgG2c, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for APOB

Target: APOB (Apolipoprotein B (APOB))

Alternative Name: Apolipoprotein B

Background:

ApoB 100, ApoB 48, Apolipoprotein B (including Ag(x) antigen), Apolipoprotein B 100, Apolipoprotein B 48, Apolipoprotein B, FLDB, LDLCQ4

Human liver or kidney tissue.

Molecular Weight: 512kDa

Gene ID: 338, 120759

UniProt: P04114

Pathways: Lipid Metabolism