Recombinant CD70 antibody (C-Term)

Catalog No. ABIN7865424

The Rabbit Monoclonal anti-CD70 antibody (Clone CD70-12768R) (ABIN7865424) specifically detects CD70 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant CD70 antibody (C-Term) (ABIN7865424)

Target: CD70 (CD70 Molecule (CD70))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD70 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: CD70-12768R

Product Details anti-CD70 Antibody

Binding Specificity: C-Term

Purpose: Recombinant CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) Antibody

Specificity: It recognizes a protein of 30 kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment corresponding to the C-terminus of human CD70 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CD70

Target: CD70 (CD70 Molecule (CD70))

Alternative Name: CD70

Background:

CD27 ligand (CD27L), CD27LG, Ki24, Surface antigen CD70, Tumor necrosis factor (ligand) superfamily, member 7 (TNFSF7)

Raji cells. Lymph node or tonsil.

Molecular Weight: 30kDa

Gene ID: 970, 501497, 715224

UniProt: P32970

Pathways: Cancer Immune Checkpoints