TARDBP antibody (C-Term)

Catalog No. ABIN7860723

The Mouse Monoclonal anti-TARDBP antibody is suitable to detect TARDBP in samples from Human. It has been validated for WB, IHC and ELISA.

Quick Overview for TARDBP antibody (C-Term) (ABIN7860723)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: TARDP-349

Product Details anti-TARDBP Antibody

Binding Specificity: C-Term

Purpose: TARDBP TAR DNA binding protein / TDP43 Antibody

Specificity: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment within human TDP43 aa 200 to the C-terminus.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TARDBP TAR DNA binding protein

Background:

TARDBP, TAR DNA binding protein 43 antibody, ALS10

Human cerebrum or colon.

Molecular Weight: 44kDa

Gene ID: 23435, 231829

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion