Cathepsin D antibody

Catalog No. ABIN7862684

This Mouse Monoclonal antibody specifically detects Cathepsin D in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Cathepsin D antibody (ABIN7862684)

Target: Cathepsin D (CTSD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin D antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CTSD-4497

Product Details anti-Cathepsin D Antibody

Purpose: Cathepsin D (Tumor Marker) Antibody

Specificity: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Purified His-tagged CTSD protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: Cathepsin D

Background:

CatD, Cathepsin D, Ceroid lipofuscinosis neuronal 10, CLN10, CPSD, Epididymis secretory sperm binding protein Li 130P, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease

A431 or SK-BR3 cells. Kidney, Liver, lung or breast., MCF-7

Molecular Weight: 48kDa (Procathepsin D), 43kDa (preprocathepsin D), 34kDa (Cathepsin D), 28kDa (heavy chain), 15kDa (light chain)

Gene ID: 1509, 654447

UniProt: P07339

Pathways: Peptide Hormone Metabolism