Recombinant COL2 antibody

Catalog No. ABIN7861123

The Rabbit Monoclonal anti-COL2 antibody (Clone COL2A1-8810R) (ABIN7861123) specifically detects COL2 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant COL2 antibody (ABIN7861123)

Target: COL2 (Collagen, Type II (COL2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This COL2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: COL2A1-8810R

Product Details anti-COL2 Antibody

Purpose: Recombinant Collagen II (COL2A1) Antibody

Specificity: The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (types I, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function. In cartilage, Collagen Type II constitutes the bulk of the fibril. Sensitization with Collagen Type II induces an erosive polyarthritis in rats, mice and higher primates which can resemble rheumatoid arthritis and relapsing polychrondritis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: bovine collagen type II (CII).

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for COL2

Target: COL2 (Collagen, Type II (COL2))

Alternative Name: Collagen II

Background:

Alpha 1 type II collagen, AOM, Cartilage collagen, Chondrocalcin, COL11A3, Collagen II alpha 1 polypeptide, SEDC

Human cartilage|lung or eye.

Molecular Weight: 190kDa

Gene ID: 1280, 17441