Desmin antibody

Catalog No. ABIN7862703

The Mouse Monoclonal anti-Desmin antibody (Clone DES-3255) (ABIN7862703) specifically detects Desmin in IHC. The antibody is reactive with Human, Dog, Cow, Horse and Cat samples.

Quick Overview for Desmin antibody (ABIN7862703)

Target: Desmin (DES)

Reactivity: Human, Dog, Cow, Horse, Cat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DES-3255

Product Details anti-Desmin Antibody

Purpose: Desmin (Muscle Cell Marker) Antibody

Specificity: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain °™-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human desmin protein

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Desmin

Target: Desmin (DES)

Alternative Name: Desmin

Background:

CMD1I, CSM1, CSM2, DES, Intermediate filament protein

SJRH30 cells. Human uterus, small intestine or leiomyosarcoma.

Molecular Weight: 52kDa

Gene ID: 1674, 594952

UniProt: P17661