Recombinant GSTM3 antibody

Catalog No. ABIN7861366

The Mouse Monoclonal anti-GSTM3 antibody (Clone rGSTM3-8878) (ABIN7861366) specifically detects GSTM3 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant GSTM3 antibody (ABIN7861366)

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GSTM3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: RGSTM3-8878

Product Details anti-GSTM3 Antibody

Purpose: Recombinant Glutathione S-Transferase Mu3 (GSTM3) Antibody

Specificity: Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, namely ±, é 79oΩ, é 79oΩ, é 79oΩ, 79oΩ, è 79oΩ, è 79oΩ and è 79oΩ, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM3 protein is selectively expressed in the testis and brain. GSTM3 may also be tumor suppressive in RCC, as low expression has been demonstrated to correlate with RCC risk and poor prognosis in post-op patients.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human GSTM3 protein

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for GSTM3

Target: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Alternative Name: Glutathione S-Transferase Mu3

Background:

brain GST antibody, brain type mu glutathione S transferase, GST class mu 3, GST5, GSTB, GSTM3-3, S (hydroxyalkyl)glutathione lyase M3, glutathione S transferase M3 (brain)

Brain|T-47D, HeLa cell lysate. Human liver|testis or kidney.

Molecular Weight: 26kDa

Gene ID: 2947, 2006

UniProt: P21266