Recombinant Integrin beta 3 antibody

Catalog No. ABIN7863044

The Mouse Monoclonal anti-Integrin beta 3 antibody (Clone rITGB3-1713) (ABIN7863044) specifically detects Integrin beta 3 in IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant Integrin beta 3 antibody (ABIN7863044)

Target: Integrin beta 3 (ITGB3)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RITGB3-1713

Product Details anti-Integrin beta 3 Antibody

Purpose: Recombinant CD61 / Integrin β3 / Platelet Glycoprotein IIIa (Platelet Marker) Antibody

Specificity: Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the ±V-chain (CD51) to form vitronectin receptor, or with the ±IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human CD61 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Alternative Name: CD61

Background:

BDPLT2, GP3A, GPIIIa, GT, HPA 1, HPA 4, Integrin beta-3, ITGB3, NAIT, Platelet fibrinogen receptor beta subunit, Platelet glycoprotein IIIa, PTP

KG1a or HEL cells. Human spleen or kidney tissues., U937

Molecular Weight: 105kDa & 90kDa

Gene ID: 3690, 218040

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex