Recombinant LRP1 antibody

Catalog No. ABIN7861645

The Rabbit Monoclonal anti-LRP1 antibody (Clone LRP1-8947R) (ABIN7861645) specifically detects LRP1 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant LRP1 antibody (ABIN7861645)

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This LRP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: LRP1-8947R

Product Details anti-LRP1 Antibody

Purpose: Recombinant CD91 / LDL Receptor Related Protein 1 (LRP1) Antibody

Specificity: Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and ±-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including ±-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human LRP1 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for LRP1

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Alternative Name: CD91

Background:

A2MR, Alpha 2 macroglobulin receptor, APOER, Apolipoprotein E receptor, IGFBP3R, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP-1, LRP-515, LRP-85, Lrp1, LRP1 protein, Prolow density lipoprotein receptor related protein 1, TbetaRV/LRP1/IGFBP3 receptor, TGFBR5, Type V tgf beta receptor

brain or lung.|Human liver

Molecular Weight: 85/515/600kDa

Gene ID: 4035, 162757

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling