OTX2 antibody

Catalog No. ABIN7863198

The Mouse Monoclonal anti-OTX2 antibody (Clone PCRP-OTX2-1E10) (ABIN7863198) specifically detects OTX2 in ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for OTX2 antibody (ABIN7863198)

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This OTX2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: PCRP-OTX2-1E10

Product Details anti-OTX2 Antibody

Purpose: OTX2 / Orthodenticle homeobox 2 (Transcription Factor) Antibody

Specificity: Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human full-lengthOTX2protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for OTX2

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Alternative Name: OTX2

Background:

CPHD6, Homeobox protein OTX2, MCOPS 5, MCOPS5, MGC45000, Orthodenticle 2, Orthodenticle homeobox 2, Orthodenticle homolog 2 (Drosophila), Orthodenticle homolog 2, Orthodenticle2, Otx 2, otx2

Colon, HeLa cells. Human fetal gut, liver or heart.

Molecular Weight: 71.5kDa

Gene ID: 5015, 288655

UniProt: P32243

Pathways: Dopaminergic Neurogenesis