Recombinant ROR gamma antibody

Catalog No. ABIN7864058

The Rabbit Monoclonal anti-ROR gamma antibody is suitable to detect ROR gamma in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant ROR gamma antibody (ABIN7864058)

Target: ROR gamma

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RORC-8017R

Product Details

Purpose: Recombinant ROR-gamma / RORC (RAR-related Orphan Receptor C) Antibody

Specificity: Retina-associated orphan receptors (RORs) contains three subtypes: RORé 79oΩ, RORé 79oΩ, and RORé 79oΩ. They are widely distributed in body tissues, and most of them can directly enter the nucleus to regulate the transcription of target genes, thus showing different tissue specificity and participating in different physiological processes. In particular, RORé 79oΩ and RORé 79oΩ play an important role in mediating Th17 cell differentiation. RORé 79oΩ can be divided into RORé 79oΩ1 and RORé 79oΩ2 (RORé 79oΩ T), which show different tissue specificity. ROR Gamma (T) is expressed only in lymphoid compartment cells, i.e., CD4+CD8+ double positive thymocytes, peripheral Th17 cells, and lymphoid tissue inducer (LTi) cells of lymphoid organs. At present, RORé 79oΩ T is considered as a new target for drug development against autoimmune diseases, especially psoriasis. In recent years, RORé 79oΩ T small molecule inhibitors have become a hot research field in academia and even international pharmaceutical companies, with great development potential.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human ROR gamma T protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details

Target: ROR gamma

Alternative Name: ROR-gamma

Background:

Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3 (NR1F3), RAR related orphan receptor C, Retinoid-related orphan receptor-gamma (RORG), Rorc, RZR GAMMA, RZRG, TOR

MOLT4 cells. Human lymphocytes. Human liver or skeletal muscle tissue.

Molecular Weight: 55kDa

Gene ID: 6097

UniProt: P51449-2