SATB1 antibody

Catalog No. ABIN7863838

This Mouse Monoclonal antibody specifically detects SATB1 in IF and FACS. It exhibits reactivity toward Human.

Quick Overview for SATB1 antibody (ABIN7863838)

Target: SATB1 (SATB Homeobox 1 (SATB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SATB1 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-SATB1-2C3

Product Details anti-SATB1 Antibody

Purpose: SATB1 (Marker of Lymph Node Metastasis of CRC) Antibody

Specificity: The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human SATB1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for SATB1

Target: SATB1 (SATB Homeobox 1 (SATB1))

Alternative Name: SATB1

Background:

DNA-binding protein SATB1, SATB family member 1, SATB homeobox 1, SATB1, Special AT-rich sequence-binding protein 1

HeLa cells.

Molecular Weight: 115kDa

Gene ID: 6304, 517717

UniProt: Q01826

Pathways: Caspase Cascade in Apoptosis, Activated T Cell Proliferation