SREBF2 antibody

Catalog No. ABIN7863432

This Mouse Monoclonal antibody specifically detects SREBF2 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for SREBF2 antibody (ABIN7863432)

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SREBF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: SREBP2-1580

Product Details anti-SREBF2 Antibody

Purpose: SREBP2 (Transcription Factor) Antibody

Specificity: The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human SREBF2protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SREBF2

Target: SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))

Alternative Name: SREBP2

Background:

AI608257, bHLHd2, Class D basic helix-loop-helix protein 2, OTTHUMP00000028740, Processed sterol regulatory element-binding protein 2, SRBP2_HUMAN, SREBF 2, Srebf2, SREBF2 protein, SREBP 2, SREBP2, SREBP2gc, sterol regulatory element binding factor 2, Sterol regulatory element binding transcription factor 2

Ubiquitous expression in adult and fetal tissues.

Molecular Weight: 68/125kDa

Gene ID: 6721, 443258

UniProt: Q12772

Pathways: Regulation of Lipid Metabolism by PPARalpha