TNC antibody

Catalog No. ABIN7864781

The Mouse Monoclonal anti-TNC antibody (Clone TNC-4805) (ABIN7864781) specifically detects TNC in IHC. The antibody is reactive with Human samples.

Quick Overview for TNC antibody (ABIN7864781)

Target: TNC (Tenascin C (TNC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNC antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TNC-4805

Product Details anti-TNC Antibody

Purpose: Tenascin C (Stromal Marker for Epithelial Malignancy) Antibody

Specificity: In Western blotting, it reacts with two bands of ~MW of 210 kDa and 300 kDa, identified as two isoforms of Tenascin C. Specificity of this MAb is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linked 79oΩhexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human full-length TNC protein

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for TNC

Target: TNC (Tenascin C (TNC))

Alternative Name: Tenascin C

Background:

Cytotactin, Glioma-associated-extracellular matrix antigen, GMEM, GP 150-225, Hexabrachion (HXB), JI, Myotendinous antigen, Neuronectin, TNC

and lung carcinomas. Staining of normal fibroblasts serves as internal positive control (IHC).|Extracellular matrix in tonsil and blood vessels. Stroma of many tumors such as breast|squamous cell

Molecular Weight: 210kDa and 300kDa

Gene ID: 3371, 143250

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development