Tryptophan Hydroxylase 1 antibody

Catalog No. ABIN7862225

This Mouse Monoclonal antibody specifically detects Tryptophan Hydroxylase 1 in IHC. It exhibits reactivity toward Human.

Quick Overview for Tryptophan Hydroxylase 1 antibody (ABIN7862225)

Target: Tryptophan Hydroxylase 1 (TPH1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tryptophan Hydroxylase 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: TPH1-7661

Product Details anti-Tryptophan Hydroxylase 1 Antibody

Purpose: TPH1 / Tryptophan Hydroxylase 1 Antibody

Specificity: Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate, and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, LDOPA, which is used as a common therapy for Parkinson s disease (PD) patients, inhibits TPH function which, subsequently, is thought to contribute to the onset of depression in PD patients.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human TPH1 protein

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for Tryptophan Hydroxylase 1

Target: Tryptophan Hydroxylase 1 (TPH1)

Alternative Name: TPH1

Background:

Indoleacetic acid 5 hydroxylase, L tryptophan hydroxylase, MGC119994, TPRH, TRPH, Tryptophan 5 hydroxylase 1, Tryptophan 5 monooxygenase 1, Tryptophan 5 monooxygenase

Human brain or kidney.

Molecular Weight: 50.9kDa

Gene ID: 7166, 591999

UniProt: P17752

Pathways: Feeding Behaviour