YY1 antibody

Catalog No. ABIN7863950

This Mouse Monoclonal antibody specifically detects YY1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for YY1 antibody (ABIN7863950)

Target: YY1 (YY1 Transcription Factor (YY1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YY1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: YY1-5436

Product Details anti-YY1 Antibody

Purpose: YY1 (Transcription Factor) Antibody

Specificity: The YY1 transcription factor, also known as NF-E1 (human) and Delta or UCRBP (mouse) is of interest due to its diverse effects on a wide variety of target genes. YY1 is broadly expressed in a wide range of cell types and contains four C-terminal zinc finger motifs of the Cys-Cys-His-His type and an unusual set of structural motifs at its N-terminal end. It binds to downstream elements in several vertebrate ribosomal protein genes, where it apparently acts positively to stimulate transcription and can act either negatively or positively in the context of the immunoglobulin k 3' enhancer and immunoglobulin heavy-chain 79oΩE1 site as well as the P5 promoter of the adenoassociated virus. It thus appears that YY1 is a bifunctional protein, capable of functioning as an activator in some transcriptional control elements and a repressor in others.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: His-tagged YY1 protein

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for YY1

Target: YY1 (YY1 Transcription Factor (YY1))

Alternative Name: YY1

Background:

CF1, Delta transcription factor, INO80 complex subunit S, NF E1, NFE1, Transcriptional repressor protein YY1, UCR motif DNA binding protein, UCRBP, Yin and yang 1, Yin and Yang 1 protein, YY-1, YY1 transcription factor

Human kidney|tonsil or cervix carcinoma tissues

Molecular Weight: 40/68kDa

Gene ID: 7528, 388927

UniProt: P25490