PAX5 antibody

Catalog No. ABIN7865710

The Mouse Monoclonal anti-PAX5 antibody (Clone IHC005) (ABIN7865710) specifically detects PAX5 in IHC. The antibody is reactive with Human samples.

Quick Overview for PAX5 antibody (ABIN7865710)

Target: PAX5 (Paired Box 5 (PAX5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX5 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: IHC005

Product Details anti-PAX5 Antibody

Purpose: anti-PAX-5 mouse monoclonal, IHC005, purified

Purification: affinity chromatography

Immunogen: Recombinant Human PAX-5

Isotype: IgG1

Application Details

Application Notes: Optional[ICC/IF_dilution]: 1:50-1:200 (microwave treatment recommended)

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Tris pH 7.3-7.7 with 1 % BSA and 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: store at 2 - 8 °C

Target Details for PAX5

Target: PAX5 (Paired Box 5 (PAX5))

Alternative Name: PAX-5

Background: PAX5 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP), whose expression is limited to early stages of B-cell differentiation. Anti-PAX5 is useful in differentiating between classic Hodgkin's lymphoma versus multiple myeloma and solitary plasmacytoma, as the protein is expressed in mature and precursor B-cell non-Hodgkin's lymphomas/leukemias while being absent from the other two conditions. Diffuse large B-cell lymphomas are positive for PAX5, with the exception of those with terminal B-cell differentiation, and T-cell neoplasms do not stain with Anti-PAX5.