TNC antibody

Catalog No. ABIN7865742

The Mouse Monoclonal anti-TNC antibody is suitable to detect TNC in samples from Human. It has been validated for IHC.

Quick Overview for TNC antibody (ABIN7865742)

Target: TNC (Tenascin C (TNC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNC antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: EBS-O-166

Product Details anti-TNC Antibody

Purpose: anti-Human-Tenascin-C mouse monoclonal, EBS-O-166, purified

Cross-Reactivity (Details): not with rat

Purification: affinity chromatography

Immunogen: protein preparation from a homogenate of a human breast cancer specimen

Isotype: IgG1 kappa

Application Details

Application Notes:

IHC-paraffin_dilution: 1:50-1:100 (1-2 μg/mL, microwave treatment in 10 mM Tris with 1 mM EDTA pH 9.0 recommended)

IHC-frozen_dilution: 1:50-1:100 (1-2 μg/mL)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: store at 2 - 8 °C

Target Details for TNC

Target: TNC (Tenascin C (TNC))

Alternative Name: -Tenascin-C

Background: EBS-O-166 specifically reacts with tenascin-C, an extracellular matrix glycoprotein of 210 kD. It recognizes those forms of tenascin that are produced by both normal and hyperproliferative (also neoplastic) tissues. Tenascin/hexabrachion/cytotactin is an extracellular matrix glycoprotein, widely expressed during embryogenesis. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyperproliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas. Positive control: Sections of carcinomas like e.g. breast cancer. Human testis.

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development