Recombinant Amphiregulin antibody

Catalog No. ABIN7867089

The Rabbit Chimeric anti-Amphiregulin antibody is suitable to detect Amphiregulin in samples from Human. It has been validated for FACS.

Quick Overview for Recombinant Amphiregulin antibody (ABIN7867089)

Target: Amphiregulin (AREG)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This Amphiregulin antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 1B12

Product Details anti-Amphiregulin Antibody

Purpose: Anti-AREG antibody(1B12), IgG1 Chimeric mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow Cyt 1/100

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Handling Advice: Avoid repeated freezing and thawing,After reconstitution, if not intended for use within a month, aliquot and store at -80 °C

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: AREG

Background:

Synonyms: AR,CRDGF,AREGB,SDGF

Target Background: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway