Recombinant IL21 Receptor antibody (PE)

Catalog No. ABIN7867339

The PE-conjugated Rabbit Chimeric anti-IL21 Receptor antibody (Clone DMC225) (ABIN7867339) specifically detects IL21 Receptor in FACS. The antibody is reactive with Human samples.

Quick Overview for Recombinant IL21 Receptor antibody (PE) (ABIN7867339)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This IL21 Receptor antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: DMC225

Product Details anti-IL21 Receptor Antibody (PE)

Purpose: PE-conjugated Anti-IL21R antibody(DMC225), IgG1 Chimeric mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow Cyt 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid PBS with 0.05 %  Proclin300, 1 % BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2°C-8°C for 6 months

Expiry Date: 6 months

Target Details for IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: IL21R

Background:

Synonyms: CD360, IMD56, NILR

Target Background: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling