Recombinant TdT antibody (AA 1-100)

Catalog No. ABIN7867840

The Mouse Monoclonal anti-TdT antibody (Clone rDNTT-6909) (ABIN7867840) specifically detects TdT in ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant TdT antibody (AA 1-100) (ABIN7867840)

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TdT antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RDNTT-6909

Product Details anti-TdT Antibody

Binding Specificity: AA 1-100

Purpose: DNTT Antibody / TdT / DNA Nucleotidylexotransferase

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1-100 was used as the immunogen for the DNTT antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the DNTT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DNTT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TdT

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Alternative Name: DNTT

Background: Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically, TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils, lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias, particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).

UniProt: P04053

Pathways: DNA Damage Repair