Recombinant TdT antibody (AA 1-100)

Catalog No. ABIN7867842

The Rabbit Monoclonal anti-TdT antibody is suitable to detect TdT in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant TdT antibody (AA 1-100) (ABIN7867842)

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TdT antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DNTT-4506R

Product Details anti-TdT Antibody

Binding Specificity: AA 1-100

Purpose: DNA nucleotidylexotransferase Antibody / TdT

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1-100 from the human protein was used as the immunogen for the DNA nucleotidylexotransferase antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the DNA nucleotidylexotransferase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DNA nucleotidylexotransferase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TdT

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Alternative Name: DNA nucleotidylexotransferase

Background: Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically, TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils, lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias, particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).

UniProt: P04053

Pathways: DNA Damage Repair