Recombinant p63 antibody (AA 1-100)

Catalog No. ABIN7867896

The Rabbit Monoclonal anti-p63 antibody is suitable to detect p63 in samples from Human. It has been validated for ELISA, IHC (p) and FACS.

Quick Overview for Recombinant p63 antibody (AA 1-100) (ABIN7867896)

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This p63 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: P40-4396R

Product Details anti-p63 Antibody

Binding Specificity: AA 1-100

Purpose: Recombinant deltaNp63 Antibody / p40

Purification: Protein A affinity

Immunogen: A portion of amino acids 1-100 was used as the immunogen for the recombinant deltaNp63 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant deltaNp63 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant deltaNp63 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Alternative Name: deltaNp63

Background: P40, the deltaN form of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential a role that may be recapitulated in tumors derived from these cells. p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial), basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.

UniProt: Q9H3D4