RAD51 antibody (AA 1-134)

Catalog No. ABIN7868105

This Mouse Monoclonal antibody specifically detects RAD51 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for RAD51 antibody (AA 1-134) (ABIN7868105)

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAD51 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RAD51-2856

Product Details anti-RAD51 Antibody

Binding Specificity: AA 1-134

Purpose: RAD51 Antibody

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 1-134 from the human protein was used as the immunogen for the RAD51 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the RAD51 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the RAD51 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for RAD51

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Alternative Name: RAD51

Background: RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.

UniProt: Q06609

Pathways: DNA Damage Repair