Iba1 antibody (AA 1-146)

Catalog No. ABIN7868167

The Mouse Monoclonal anti-Iba1 antibody (Clone AIF1-2493) (ABIN7868167) specifically detects Iba1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Iba1 antibody (AA 1-146) (ABIN7868167)

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Iba1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AIF1-2493

Product Details anti-Iba1 Antibody

Binding Specificity: AA 1-146

Purpose: AIF1 Antibody / IBA1

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 1-146 from the human protein was used as the immunogen for the AIF1 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Titering of the AIF1 antibody may be required for optimal performance.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the AIF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Iba1

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Alternative Name: AIF1

Background: AIF1 (Allograft inflammatory factor 1), also called IBA1 (Ionized calcium-binding adapter molecule 1) is a cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. AIF1/IBA1, containing two EF domains, is induced by cytokines and Interferons. In an unstimulated state, it colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding the protein resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC).

UniProt: P55008

Pathways: Smooth Muscle Cell Migration