Recombinant Podoplanin antibody (AA 1-150)

Catalog No. ABIN7868186

This Rabbit Monoclonal antibody specifically detects Podoplanin in ELISA, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant Podoplanin antibody (AA 1-150) (ABIN7868186)

Target: Podoplanin (PDPN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Podoplanin antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PDPN-8875R

Product Details anti-Podoplanin Antibody

Binding Specificity: AA 1-150

Purpose: Glycoprotein 36 Antibody / Gp36 / Podoplanin

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-150) from the human protein was used as the immunogen for the Glycoprotein 36 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Glycoprotein 36 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Glycoprotein 36 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Podoplanin

Target: Podoplanin (PDPN)

Alternative Name: Glycoprotein 36

Background: It recognizes a muco-protein of 38-43 kDa, which is identified as Podoplanin (PDPN), also called Glycoprotein 36 (Gp36). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

UniProt: Q86YL7

Pathways: Dicarboxylic Acid Transport