PIN1 antibody (AA 1-163)

Catalog No. ABIN7868227

The Mouse Monoclonal anti-PIN1 antibody (Clone 5E5-) (ABIN7868227) specifically detects PIN1 in WB, IF and FACS. The antibody is reactive with Human, Rat and Monkey samples.

Quick Overview for PIN1 antibody (AA 1-163) (ABIN7868227)

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Reactivity: Human, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This PIN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 5E5-

Product Details anti-PIN1 Antibody

Binding Specificity: AA 1-163

Purpose: PIN1 Antibody / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-E163) was used as the immunogen for the PIN1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the PIN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PIN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PIN1

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Alternative Name: PIN1

Background: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

UniProt: Q13526