Angiopoietin 1 antibody (AA 1-200)

Catalog No. ABIN7868369

This Mouse Monoclonal antibody specifically detects Angiopoietin 1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Angiopoietin 1 antibody (AA 1-200) (ABIN7868369)

Target: Angiopoietin 1 (ANGPT1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Angiopoietin 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ANGPT1-3651

Product Details anti-Angiopoietin 1 Antibody

Binding Specificity: AA 1-200

Purpose: Angiopoietin 1 Antibody / ANGPT1

Purification: Protein G affinity

Immunogen: A portion of amino acids 1-200 from human AGPAT1 protein was used as the immunogen for the Angiopoietin 1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Angiopoietin 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Angiopoietin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Angiopoietin 1

Target: Angiopoietin 1 (ANGPT1)

Alternative Name: Angiopoietin 1

Background: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema.

UniProt: Q15389

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process