FAP antibody (AA 1-200)

Catalog No. ABIN7868481

The Mouse Monoclonal anti-FAP antibody is suitable to detect FAP in samples from Human. It has been validated for IHC (p).

Quick Overview for FAP antibody (AA 1-200) (ABIN7868481)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAP antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FAP-4854

Product Details anti-FAP Antibody

Binding Specificity: AA 1-200

Purpose: FAP Antibody / Fibroblast Activation Protein Alpha

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1-200 was used as the immunogen for the FAP antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the FAP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the FAP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Alternative Name: FAP

Background: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

UniProt: Q12884

Pathways: Tube Formation