FAP antibody (AA 1-200)

Catalog No. ABIN7868482

The Mouse Monoclonal anti-FAP antibody (Clone FAP-4853) (ABIN7868482) specifically detects FAP in IHC (p). The antibody is reactive with Human samples.

Quick Overview for FAP antibody (AA 1-200) (ABIN7868482)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAP antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: FAP-4853

Product Details anti-FAP Antibody

Binding Specificity: AA 1-200

Purpose: Fibroblast Activation Protein Alpha Antibody / FAP (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1-200 was used as the immunogen for the Fibroblast Activation Protein Alpha antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the Fibroblast Activation Protein Alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Fibroblast Activation Protein Alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Alternative Name: Fibroblast Activation Protein Alpha

Background: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

UniProt: Q12884

Pathways: Tube Formation