Recombinant MYH11 antibody (AA 1-200)

Catalog No. ABIN7868669

This Rabbit Monoclonal antibody specifically detects MYH11 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant MYH11 antibody (AA 1-200) (ABIN7868669)

Target: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MYH11 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MYH11-8185R

Product Details anti-MYH11 Antibody

Binding Specificity: AA 1-200

Purpose: SMMHC Antibody / MYH11

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the SMMHC antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the SMMHC antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SMMHC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MYH11

Target: MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))

Alternative Name: SMMHC

Background: Smooth Muscle Myosin, heavy chain (SMM-HC) is a cytoplasmic structural protein that is a major component of the contractile apparatus of the smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early and is specific for smooth muscle development. SM-MHC stains the intact myoepithelial cell (MEC) layers present in benign and in situ malignant breast and bronchioloalveolar lesions and is therefore very helpful in distinguishing between benign and malignant tumors. The antibody reacts with smooth muscle cells and myoepithelial cells, but not with myofibroblasts. It is very helpful in distinguishing between benign sclerosing breast lesions and infiltrating carcinomas in difficult cases since it strongly stains the myoepithelial layer in the benign lesions while it is negative in the infiltrating carcinomas.

UniProt: P35749