PAX4 antibody (AA 1-200)

Catalog No. ABIN7868697

The Mouse Monoclonal anti-PAX4 antibody is suitable to detect PAX4 in samples from Human. It has been validated for IHC (p).

Quick Overview for PAX4 antibody (AA 1-200) (ABIN7868697)

Target: PAX4 (Paired Box 4 (PAX4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PAX4-7598

Product Details anti-PAX4 Antibody

Binding Specificity: AA 1-200

Purpose: PAX4 Antibody / Paired box 4

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the PAX4 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the PAX4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the PAX4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PAX4

Target: PAX4 (Paired Box 4 (PAX4))

Alternative Name: PAX4

Background: Pax-4 (paired box gene 4) protein influences normal differentiation of Insulinproducing beta cells and influences normal pancreatic islet development. Pax-4 protein is a transcriptional repressor that binds to a common cis element in the Glucagon, Insulin and Somatostatin promoters. Mouse Pax-4 transcript is present in pancreatic islets, and the islet beta cell lines MIN6, beta TC and NIT1. Differentiation of endoderm-derived endocrine pancreas is mediated through Pax-4 and Pax-6. Pax-4 may act as a Pax-6 repressor due to the competition for binding sites and lower transactivation potential of Pax-4. The human Pax-4 gene encodes a deduced 350 amino acid protein that is 80 % identical to the deduced mouse Pax-4 protein.

UniProt: O43316