Syndecan 1 antibody (AA 1-250)

Catalog No. ABIN7868954

This Mouse Monoclonal antibody specifically detects Syndecan 1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Syndecan 1 antibody (AA 1-250) (ABIN7868954)

Target: Syndecan 1 (SDC1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Syndecan 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SDC1-7178

Product Details anti-Syndecan 1 Antibody

Binding Specificity: AA 1-250

Purpose: Syndecan-1 Antibody / CD138 / SDC1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-250) from the human protein was used as the immunogen for the Syndecan-1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Syndecan-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Syndecan-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Syndecan 1

Target: Syndecan 1 (SDC1)

Alternative Name: Syndecan-1

Background: CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma.

UniProt: P18827

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism