RAD17 antibody (AA 1-267)

Catalog No. ABIN7869008

This Rabbit Polyclonal antibody specifically detects RAD17 in WB, ELISA, FACS and IHC (p). It exhibits reactivity toward Mouse and Rat.

Quick Overview for RAD17 antibody (AA 1-267) (ABIN7869008)

Target: RAD17

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RAD17 Antibody

Binding Specificity: AA 1-267

Purpose: Rad17 Antibody

Purification: Affinity purified

Immunogen: Recombinant mouse protein (amino acids M1-Q267) was used as the immunogen for the Rad17 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Rad17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Rad17 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RAD17

Target: RAD17

Alternative Name: Rad17

Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

UniProt: Q6NXW6