HSD17B8 antibody (AA 1-336)

Catalog No. ABIN7869210

The Rabbit Polyclonal anti-HSD17B8 antibody is suitable to detect HSD17B8 in samples from Human. It has been validated for WB, ELISA and IHC (p).

Quick Overview for HSD17B8 antibody (AA 1-336) (ABIN7869210)

Target: HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HSD17B8 Antibody

Binding Specificity: AA 1-336

Purpose: RING2 Antibody / RNF2 / RING1B

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-K336) was used as the immunogen for the RING2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RING2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RING2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HSD17B8

Target: HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8 (HSD17B8))

Alternative Name: RING2

Background: E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene. Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

UniProt: Q99496

Pathways: Steroid Hormone Biosynthesis